I just brought my cat down by car from Massachusetts in January. She hates to travel but handled the 20 hour drive quite well. In fact, I have traveled with one or two cats for the last 20 years by air and by car. Cats are unique in that they can basically shut their entire system down. I have traveled 20 or more hours with my cats and they stayed in their crate. They did not/would not pee and for the most part would not eat or drink for me even though I tried to feed them. By the end of every trip, they were fine and went about their life as if nothing was different after they investigated their new surroundings. Of course, some cats may be a little higher strung than mine were. If you are taking your time getting here, you don't want to have to keep giving them tranquilizers. I did not sedate either of my cats and they did a LOT of traveling. Just leave them in the crate and they will settle down. You might even put a towel over their crate so they don't get nervous with all the goings on around them. They are not like dogs who love to look out the window.
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