When we went back and forth with our dogs, we never had to drug them. They enjoyed the ride. Would sleep most of the time on the seat between us. Just stop and let them do their business ever so often and stretch their legs. When we stopped to eat, we would leave the car running...doors locked...and made sure we had the other set of keys with us (not locked in the car). I would run out ever so often to make sure the car was still running. I was overly concerned. Never had any problem, though. They loved to travel.
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