I always use Google Maps. They show 3 choices:
1) the northern route - 42 to 44, 63.7 miles, 1 hr 26 min.
2) the southern route - the Turnpike to 408 to 417, 84.3 miles, 1 hr 23 min plus tolls
3) the straightest route - 441 to 46, 58.8 miles, 1 hr 30 min
As you can see, there is not much difference and one route will cost money because of tolls. I haven't been to the airport but I have gone to the Autotrain station twice in Sanford, and I always take the straight route. You do get traffic on 441, but I like stuff to look at while driving rather than just pine trees.
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