Some will argue I-10 to I-75 Lake City, then I-75 south, that way you'll avoid the speed traps at Starke, Waldo and Citra and others, but you'll add 60 miles to your trip. I was born in Baltimore and raised in the Tampa area, plus lived in Savannah for ten years and now TV for almost 5 years, I've driven this route at least 100 times.
Using Google Maps, from I-95 Jacksonville Airport exit to TV is 168 miles and 2 hrs and 54 minutes. From Georgia continue south on I-95 when approaching Jacksonville look for I-295 bypass. Takes I-295 bypass to I-10 West, take I-10 west until US 301 and exit US 301 south. US 301 south is a 4 lane divided hwy. When approaching Ocala look for CR 326 (should have an I-75 sign), take 326 west until I-75. Take I-75 south until SR 44 east Wildwood exit. Take 44 until you reach TV.
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