As far as commuting, living near one of the major roads is the best concept. I drive to Gainesville every single day - living right off 466 (or 466A, south, or 42/441, north). We lived on the north side of 466 for about 6 months, then moved just south of it (you could say, "closer to the middle".
The best ideas are 1) avoiding having to go through lots of roundabouts; 2) picking your route and understanding the alternates (more on that later); 3) testing a location. I can tell you from my experience that I-75 is faster, but sometimes too fast - people drive like the Grand Prix is going on, often. 441 is slower, stop lights through small burgs, etc. But - you need to know all the routes, as traffic accidents are not uncommon on either.
Lopez area had great homes, nice people - but many of the ones we looked at last year needed serious "renovation", as they are older. Some have already been renovated, some not. The area does have more "yard" per house, and it also has lots of vegetation (oak trees are huge - that's good and bed, they shed leaves a lot).
I don't like the train noise, some love it. Your call there. Getting to Town Squares/Woodshop? It's a hike by golf cart from some sections (further west - longer trip).
So, it's all your choice. But, beware the commute thing. Sometimes it's faster to drive down I-75 to the 44 exit (Wildwood) and live south; sometimes it's faster to jump off at 484, scoot over to 301, and voila! You're at the north end. Plus, double-bonus of living north - you'd be close to not one but TWO Wal-Marts!
