I have been using esomeprazole (Nexium) for over a decade and have recently started having terrible abdominal pain and bloating. I went to the Dr and he wanted me to start doubling my dose but I was not going to do that as I have been reading that long term usage of PPIs can lead to Alzheimers and Kidney failure. Instead, I halved my dosage and also started with the apple cider vinegar and I am feeling much better. Next I plan to stop the esomeprazole altogether but I have also read to do it slowly to not suffer the rebound. Turns out as we age our stomachs start producing less acid and the effects of this are abdominal pain, indigestion and bloating. The doctors are far too anxious to write scripts.