As KayakerNC posted, the Hyatt Regency is as close to the action as you can get. I watched that place get built. It hangs right out over River St., that's the cobblestone street with the tracks running down the middle.
On the right side looking westward toward the hotel is the Savannah River, the dividing line between Georgia and South Carolina. On the left is several blocks of buildings that are 3 stories tall. They were cotton warehouses in the 1800's. They have been converted for commercial use. The bottom floor faces River Street and they are usually bars, restaurants and gift shops. The top floor faces the opposite direction, which is Bay Street and they contain everything from a Flag Shop to Real Estate to Attorneys.
My first job when I got out of the Army in 1972, I was stationed in Savannah at Hunter AAF, was working for Southern Railroad as a switchman. We use to make deliveries to Dixie Sugar Factory which was about 5 miles east of River Street, and that was only way to get there was to bring the train right down that way. Back then there was very little parking. The river started maybe 10' from the tracks, so it was not uncommon for people to park cars all along the tracks and we would to run into the bars looking for the owners of the cars to move. Later in the 70's and 80's they dredged in more land and made parking lots and that took care of the problem.
Savannah has the second largest St. Patrick's Day Celebration in the US. There is usually about 300,000 people downtown in a city of 150,000 on that day, to watch the parade and drink a lot of green beer. I went once and that was enough for me. I almost owned one of those bars on River Street, as it turned out I opened a Record store instead.
An Irish Pub who had great business decided to buy the bar next door to eliminate competition. It turned out to be more hassle and they barely broke even because they didn't invest in any entertainement or food, etc. They listed for $65,000 and I looked at it with an appraiser and offered them $35,000. They didn't own the building, it had lease and there wasn't much good will to buy since they had run the business into the ground. They didn't accept my offer and then 3 weeks later called me back to say they accepted, sorry I already moved on. My plan was to make it a comedy club, as it turned out, the fellow who did buy the place made it a comedy club and I went there many times, he did a great job.
I liked Savannah a lot, probably lived there for 10 years all together in the early 70's and then much of the 80's. Haven't been back very much since then. When I look at maps I can see they it has really grown. When I was in the Army I lived in a trailer out off of Skidaway Drive. There was a bridge next to my trailer park that went to an island but nobody lived there and nobody ever went across. Then in the late 70's and 80's it was developed into Skidaway Island. It a beautiful place with low country type homes and a golf course. It's sort of a mini Hilton Head. In fact when I would travel to Hilton Head back then, there was hardly anything there. Enjoy your trip.