The all-in-ones are really nice and save a lot of space. They're especially nice with a touch screen which take a little time to get used to but are a real nice alternative to using a mouse. The biggest issue (for me) is the all-in-1s are built of laptop components which are difficult to find replacements for if any go bad on you. (Standard desktops are *usually* built from interchangeable parts which are easily swapped out).
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