A lot of people ,especially older persons with arthritic hands, IMHO should not carry an auto-loader, they may not be able to clear a malfunction--they should stick with a wheel gun in a comfortable caliber--I was taught how to combat shoot by a former Mossad member-they carry with an empty chamber and the safety off-- with todays DA only pistols without a safety its totally ok to carry with a round chambered--best advice is equip your carry weapon with a laser sight-takes out a lot of the adrenal rush and guarantees you are on target--remember you are responsible once the weapon is exposed fired or not
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