"Buck" was not only CGI, but movements etc were done with a human actor playing the dog.
From a USA TODAY article>
The new screen adaptation of Jack London’s famed 1903 novel, set in the 1890s Klondike Gold Rush, features an unusual screen pairing: Ford and "Planet of the Apes” motion-capture actor Terry Notary, who plays Buck.
Having the human actor, who was digitally transformed into the massive sled dog, helped Ford. “I had an emotional relationship with this consciousness that was Terry Notary. And he became the consciousness of Buck,” he says.
Question: In those scenes where you are patting Buck on the head, was it hard getting used to head-patting Terry Notary?
Harrison Ford: Petting him on the head wasn’t the weird part. Rubbing him on the belly was a little weird at first. We got over it real quick. It just becomes normal.
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