Turnpike all the way, until it runs out...and merges with I-95.
Google Maps may show about 15 minutes quicker by jumping on 95 at Ft. Pierce, but after having made this trip many times, I've found the odds of getting backed up on the Turnpike much less...than on 95.
Regardless of which route you choose, be ready for a backup due to a wreck/disabled vehicle...either way you go.
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