We transported 4 cats from Chicago to TV and I guess we were really lucky.
We have a van, so two huge dog crates in back, two cats in each, fully equipped with disposable litter boxes, food and water. All of our cats were chipped before we left and numbers sent to database. Then mild tranquilizer the first day and didn't need any the second day. They must have liked the
hum of the engine. Very calm, never cried. I would talk to them on and off.
Ate only at drive-thru places, because I wouldn't leave them alone outside. And stayed in a pet friendly Comfort Inn.
I was terrified of the move, but all went extremely well. Thank goodness!