My $.02
There are 2 types of possibilities, one is that a franchisee is going to open it up and the other would be a corporate run store. If it's a franchisee (that knows what they're doing) then they should stand a good chance. They most likely will do whatever is necessary to ensure its success. With a manager from a corporation in charge with no vested interest, it might not be managed so well.

Perhaps this location for this type of business will bear the needed traffic in order for it's success/survival.

Perhaps the location on 466 didn't have the demographics for that particular business, yes many vehicles passed by but how many potential customers were not going down 466? Now Culvers is a unique business and has a huge following. Where DQ isn't anything special. Just my opinion.

US 301 has a much different traffic demographic and potentially could grab more passerby customers to ensure its opportunity for success.

Not every business wants/needs to be a golf cart accessible business.

If a franchisee is attempting to open up during this difficult time, I wish them well and hope for their success.