When I read my first Patterson book I didn't know there was a series of Cross books. My first was I believe his third or fourth. The one I read next was another random one in the series. I've read a few of them and had no trouble "keeping up" with the character evolution. Patterson includes enough information in each book to "update" the reader on any significant changes in the cast of characters.
Each book can stand alone if you choose to read them independent of the others.
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