https://www.nejm.org/doi/full/10.1056/NEJMoa2016638
Another recent study again in the New England Journal looking at using HCQ as a preventative in exposed people, specifically high and moderate risk exposure meaning close contact for greater than 10 minutes to a known positive.
Conclusion
Quote:
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Overall, 87.6% of the participants reported a high-risk exposure to a confirmed Covid-19 contact. The incidence of new illness compatible with Covid-19 did not differ significantly between participants receiving hydroxychloroquine and those receiving placebo .... Side effects were more common with hydroxychloroquine than with placebo (40.1% vs. 16.8%), but no serious adverse reactions were reported.
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The most
recent meta analysis [looking at all published data and combining the results] pre-published on Jul 24 using all data available through Jul 19 concludes:
Quote:
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The results of the meta-analysis on comparative studies indicated no significant clinical effectiveness .. for HCQ regimen in the treatment of COVID-19 in comparison to control group ... The same result was observed for the combination of HCQ+azithromycin ... No significant differences were found for both HCQ ..and HCQ+AZM .. mortality rate; however, mortality was affected by age differences according to meta-regression analysis (P<0.000001). No substantial difference was observed for disease exacerbation .. between HCQ group and controls. Also, radiological findings significantly improved in the HCQ group (... Odds of known HCQ adverse effects (diarrhea, vomiting, blurred vision, rash, headache, etc.) occurred in the HCQ regimen group was approximately 3.5 times of control group .., but no substantial differences were found regarding intubation odds between HCQ... Meta-analysis indicated no significant prophylactic effects for HCQ .. Conclusion: This systematic review and meta-analysis showed no clinical benefits regarding HCQ treatment with/without azithromycin for COVID-19 patients. Although mortality rate was not significantly different between cases and controls, frequency of adverse effects was substantially higher in HCQ regimen group.
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[my bold]
Now tell me again about how the studies prove that HCQ is beneficial. The final result is not yet in. There are large ongoing randomized studies, but an unbiased look at the conflicting data so far available has overwhelmingly concluded that HCQ benefit is about as likely as that
endometriosis is caused by having dreams about sex with demons.