From my house in Belleair to the intersection of US 301 and I 10 is 100 miles and two hours. If you elect to go around Ocala by using I 75 and getting on US 301 above Ocala you will add about six miles but the time is about the same.
I have made this trip countless times and I have tried alternatives but this is my preference.
Speed limits are clearly marked and there is zero tolerance. If you exceed the limit you will stand out like a sore thumb. I just set my cruise control on 45 and relax.
Having family in St. Augustine I use the routing Indy-Guy suggests for trips there.
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