I have several medium bushes and trim them through out year, some way back. So far I haven’t killed one yet. I have two tree/big holly bushes trimmed one way back on retaining wall side and shaped it. The tree shaped as pointee bush had junk palm the grew up in it crating big bare spot. I cut the palm out and it took about 3 years for fill in hole. I do this throughout the year, so IMO you can trim away basically throughout the year. I also pull all the sucker parasites off which IMO rob the plant from looking healthy.
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