Quote:
Originally Posted by msilagy
You do not have to start over. The person that said that is not only clueless but has a limited thought process. It is true there is 80% coverage for Moderna at the end of 28 days but what is unknown is how long that will last without the booster. In Moderna's trials efficacy 1 week after 2nd shot is 94.5% but in over 65 drops to 86%. They did a subset of over 65 and that was the result. No big deal tho. This is fact - look up clinical trials and these facts are there.
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Additional info on single dose:
How effective is a single vaccine dose against Covid-19? - BBC Future
Thought this point of view interesting where an alternate Pfizer estimate is based on when the initial injection likely becomes effective.
"But there is also another figure that has been circulating on the internet, and anecdotally, being fed to patients by certain doctors – the suggestion that the first dose is around 90% effective. And this is where it gets a little more complicated.
The second estimate comes from the UK's Vaccine Committee, the JCVI, who decided to calculate the efficacy of the vaccine differently.
Instead of using all the data on the number of infections, including from days when the first dose hadn't yet started to work, they only looked at days 15-21.
Using this method, the efficacy of the vaccine jumps up to 89%, because it's not being diluted by the relatively high number of infections before the vaccine begins to have an effect.
Taking things even further and only looking at the first seven days after the second dose (days 21-28) – because the second dose might not have kicked in yet by then – it's 92%.
However, these calculations are controversial."