Heterologous immunity is where an immune response to two pathogens can increase or decrease a response to a different pathogen
So what does that mean? While both Pfizer and Moderna target the spike protein the immune response is probably different .
So far so good right? You may cover multiple strains and never have to worry about any sars-cov-2 pathogen that enters your body.
The problem lies in that these immune responses can trigger severe immunopathology to self antigens.
I.e. you give yourself autoimmune disease. The chance is low but it is not zero. For this reason it is a bad idea to get multiple vaccines for the same disease.
Not only that, if you had a strong immune response to a prior vaccine, you'll probably be laid up for a day or two as your body mounts a massive response to vaccine #2.
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