The immunologist at the clinical trial said the jury is still out on this one so recommend trying to tough it out if possible.
Common questions about COVID-19 vaccinations answered – Mayo Clinic News Network
Is it safe to use fever-reducing pain medications like acetaminophen before or after receiving the COVID-19 vaccine?
Whether you’re receiving your first or second dose of a COVID-19 vaccine, do not take fever reducing and pain medications such as Tylenol, Feverall and ibuprofen before being vaccinated just to prevent reactions that haven’t yet happened. Doing so may dampen your immune response. If you do have a moderate headache or body ache as a reaction to being the vaccinated for COVID-19 , you can take such medications as needed to treat that pain