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Originally Posted by Tmarkwald

Preclinical work on therapeutic mRNA goes back at least to 1990, 20 years ago...

Want to Know More About mRNA Before Your COVID Jab? | MedPage Today

Never Been Done Before?

While an mRNA vaccine has never been on the market anywhere in the world, mRNA vaccines have been tested in humans before, for at least four infectious diseases: rabies, influenza, cytomegalovirus, and Zika.

mRNA can target tumor-associated antigens expressed mainly by cancerous cells, like certain growth factors. These vaccines have been tested in a range of cancers, including acute myeloid leukemia, multiple myeloma, glioblastoma, melanoma, prostate cancer, and others.

Why Did Earlier Vaccines Stall?

"A major factor is that there's not a sense of urgency," Dennis Burton, PhD, of Scripps Translational Research Clinic in La Jolla, California, told MedPage Today.

Zika has been relatively contained; rabies vaccines are already sufficiently effective; and influenza remains a difficult target, Burton said.

...based on the sheer number of people who will be vaccinated for COVID-19, events will occur, and most will likely be unrelated to the vaccine.

"One of the things we're most concerned about is that people won't get vaccinated," he said. "But the risks of this disease are going to be way higher than the risks associated with vaccination."

“Clinical trials for 75,000 people show it’s safe and it’s 95 percent effective,” Dr. Weissman said. “That’s pretty good data to convince people that it is OK.”
While mRNA is a new technology, experts have been working on it for years.

“It’s not just as though these technologies were just starting to be developed during the pandemic,” Dr. Moss said. “There has been a lot of preparatory work.”


This is part of The Associated Press’ ongoing effort to fact-check misinformation that is shared widely online, including work with Facebook to identify and reduce the circulation of false stories on the platform.

Pfizer and Moderna did not skip animal trials

Fact check by the associated press or any other press seems these days to mean editing and deleting any information they don't want you to have. The word "they" refers to many entities filtering information and free speech. When did all the social media become the decider of what news is made available to the public? I for one am perfectable of deciding for myself what I believe or disbelieve, I don't need the press and social media owners doing that for me.