[Malsua]

Originally Posted by coffeebean

Is the following piece an opinion piece? I don't think so as it seems to follow scientific principles. This is really good news regarding the mRNA vaccines.

Which is better for developing immunity: COVID-19 vaccine or natural infection? – Daily Breeze

I would only caution that while it might be true, something jumped out at me reading this article.

The spike protein is big, Felgner said. And in natural infections, the virus manages to hide this vital receptor so the immune system doesn’t see it.

I'm not sure what Philip L. Felgner, director of UC Irvine’s Vaccine Research and Development Center and Protein Microarray Laboratory and Training Facility, is getting at here.

Both in natural and vaccination, the receptor binding domain on the spike protein is pretty much the same place the immune system targets. At least as far as most of what I've read about it is suggesting.

The immune system is very complex and it is quite possible that the immune system in a natural infection picks up different protein chains that aren't part of the spike protein or different motifs on the spike protein rather than specifically on the binding domain. I don't know, but to say that the natural virus "hides" it? How? If the RBD is sheathed or not exposed, it simply won't work and we know that it works, so what is he on about here?