When I had my plane at LEE I was told that "the family" was very interested in extending the runway so they could make a full fuel departure with their G3 and Falcon 500. Need the fuel load to fly to Europe and the west coast. They did have another Falcon on order instead of a G5 because the parts would be interchangeable with the three falcons. Getting a G3 or G5 out of LEE is no problem so I'm sure a regional airline could land here. There is a published GPS(RNAV) & NDB approach, but no ILS.
http://www.airnav.com/airport/KLEE for further info.