Quote:
Originally Posted by Malsua
Actually, if you understand how gain of function research has occurred in the past, you would know that they insert a polybasic furin cleavage site into a virus. They do this so that a protease can come along and snip the receptor binding domain off the viral genome which allows the viral payload to be inserted into the cell.
There are 13 documented occurrences of this on various other viruses.
They used a polybasic furin cleavage site with a proline, two arginines and an Alanine. PRRA.
PRRA has high affinity for human tissues which is why it is a good insert for gain of function.
PRRA is not found in animal models like bats, pangolins or most of everything that isn't humanized because their systems don't code for a protease like humans do.
There are no bat ancestor genomes with a polybasic furin cleavage site with PRRA. In fact, that probably would not occur in nature because it would make it harder for the virus to propagate in bat tissues.
Sars-Cov2 has a polybasic furin cleavage site PRRA. Is that proof it came from a lab? without someone admitting they did that, no, not exactly. It's a smoking gun though.
It is the exact sequence used in gain of function. We know bat genomes were used at the Wuhan Institute of Virology. We know the Bat lady, Shi was using that exact sequence in gain of function research.
When you are in North America and you hear hoofbeats, you don't think zebras.
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You seem to have a lot of knowledge on the subject. As you probably know, Sars-Cov1 did have an animal intermediary, as did MERS. They've never found the animal this time even though the Chinese claimed they had only to be refuted and exposed by other scientists. The genome sequence needs to be almost as exact match and the closest they ever got was 96%.
The Chinese were present when they did the gain of function research at Univ. of North Carolina lab where they successfully infected HeLa cells (human cells) with horseshoe bat coronavirus. So the Chinese just continued on with it in Wuhan, along with other bioweapons research. Although virus escapes have happened, this was no accident. Not with the timing of it and then the elaborate cover up and lies by the Chinese. As late as mid-January, at least two months after the first COVID case, knowing full well what was happening in their country they still permitted travel abroad.
Nice "business partners", eh?