It’s not a difficult drive. We go every year for a week. 1st day we leave about 11 or 12 drive to Naples or Marco island, have a nice dinner, next day we have breakfast and leave via the Tamiami Trail through the Everglades, we do this because we like to eat lunch at Sparky’s Landing in Marathon and stop for a Bloody Mary at Sunset Point Bar that overlooks the 7 mile bridge also if it’s stone crab season Keys fisheries in Marathon is great for claws. Spend our week in KW and when we leave we drive straight home via the turnpike, 7-8 hours depending on traffic and stops. You can fly Silver Air from Orlando or Tampa direct to KW but you miss so much of the other keys.
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