We drive from MA, about 22 hours with the dog. We follow the gps and it usually takes us just south of DC and then we use the express lane if open. Once it took us 301 which was easy. We use to leave at about 5PM and drive through but after a few trips the 2AM-5AM time got tough. We starting staying over night in Virginia. The last couple times we left at 5AM and drove straight through and got here about 1-2AM.
Good luck and safe travels.
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