I run CCleaner every once in awhile. It cleans up those temp files, clears the cache and browsing history, and then removes redundancies or erroneous entries in the registry that can happen when you run a cleanup like that. I also run malwarebytes once in a blue moon. I used to pay for both of these programs but the freebies are doing fine for me - and I don't get stuck with a lot of nags from them to renew or "go pro."
If it's a .tmp, you can safely delete it. If it's a tmp that's attached to a program that's actively running, you won't be able to delete it, you'll get an error message. If that happens, it's working as intended.
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