If you are talking about a pc running windows (why anybody would be running windows in the 1st place is alarming) and the computer has been modified with 3rd party hardware and drivers, I would stay away because it might be a headache to keep everything updated, plus the latest OS has issues running on certain hardware.
If it’s a Mac from 2012 or newer, no problem buying used/refurbished. The main reason is the only thing you can modify inside a Mac is the amount of memory (sometimes), laptop batteries, and hard drives/ssd. If the mac boots up and sees all the memory, the memory is good. You can run disk utility to see if the hard disk/ssd has any errors.
You can also check the laptop battery.
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