We don't make the drive anymore from Finger Lakes NY, but have done it. Depends on how long you want your driving "legs" to be, but we drove from NY to Florence, SC in one shot and then the rest of the way next day.
It's just off 95, so may not be what you want, but it's a complex with a bunch of national chain hotels and restaurants. Walkable area. Very pleasant for one overnight. Here are the coordinates:
Hotel center:
34°11'12.99"N
79°50'6.79"W
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