For our first trip, I bought a video game steering wheel that clamps to your desk. I practiced with that for a while driving a left side simulator. It really helped.
Use iMaps or other nav app. I'd say all new cars allow you to connect to the dashboard screen. Following the blue nav line on the screen the "wrong" way around roundabouts is very helpful.
Several people suggested having an involved navigator next to you. That's a good idea, but a distracted one is worse.
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It's all downhill from here!
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