The more you have handled kitty, the easier it will be. Locating and swaddling your cat in a bath towel usually calms them if they are skittish. Be gentle and talk to them. If using capsules I gently open the jaw just enough to insert pill and hold other hand on the other side to avoid spit outs. Just insert and hold mouth closed for a couple of seconds, maintaining the cat tightly in the towel. Hopefully nails have been clipped. I do that the night before.
You might call mobile groomers and see if they can do this for you also.
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