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I agree that the investigative and deductive powers portrayed in "House" are a pretty good example of what Holmes might have done were he a physician. But I would argue with your use of "Doyle characters". That suggests that Doyle invented something. The truth is that Doyle was merely Watson's literary agent and was responsible for the fine tuning and eventual commercialization of the few cases Watson allowed to be published. Watson was a decent physician and an adequate (at times) companion and Boswell, but he was not the best businessman.
Had Holmes had his way, nothing would have been published and he was quite disappointed that Watson chose to renege on the gentlemen's agreement to "chronicle but not publish". To this day, Holmes contends that his association with Watson was, on balance, not positive.
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Ah, I see where this is going. I loved the Rathbone/Bruce movies but felt they were not as much in the spirit of Holmes as the Britt series. My god, we have Holmes fighting the Nazis! He would have had to be 120 years old. Anyway, I think the Bruce character was far too bumbling (ok, I like that) to be Watson. The Britt series had high production values and a true Holmes feel.
House is much in the spirit of Holmes. We have House/Holmes, Watson/Wilson, a single friend, THE woman, the drug problem and even an apartment number 221B! Anyway, if you want to see a great series ruined by a modern movie, watch the AMC series "The Prisoner". It makes Downey's Holmes seem on the mark. But that is a post for another time.