I think the route you take is all about personal preference and how you like to drive. I have tried the 301 route, the 314 through Palatka and the 40 to Ormand Beach. Also I have driven the 42/44 route to New Smyrna Beach a number of times. Each has it pluses and minuses but for me I like the 40 through the forrest.
For me I drive non stop from Ohio and it is about is about an 16 to 18 hours depending on now long the pit stops are, traffic, and a 15 minute power nap here and there. I just like to set the cruise control, throw on some good tunes, have a couple of bottles of water handy and some trail mix or something to munch on and I am good to go. Being excited about getting to TV also helps.
So traveling in this manner I like the 40 route as it may have the least amount of stop and go driving once you leave I-95 going . I have gone through the forrest in the early am hours and it was never a problem. I think the small added distance can be made up by the travel time on I-95 and 40.
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