Rt 466 is just kind of a natural border. It's significant (in my mind) only in that to cross it on a golf cart, you need to go thru a tunnel, either near Buena Vista or Morse Blvd. There are many other tunnels on the multi-modal paths, but to cross 466 it's a little bigger deal (in my mind, anyway). Not difficult (except for the Morse Blvd bridge), just takes a little longer.
It's also kind of how you figure your golf cart transit time from wherever you live. Kind of like, "let's see, it takes me x amount of minutes to get to the tunnel, should be about x more minutes to get to y.
For some, it may be the line where they decide to drive the car rather than the golf cart. If you live very far north of it, you may tend to shop and use the golf courses north of it, vice versa if you live south of it. When Brownwood Paddock (I think that's the name) is completed, that will be south of 466A, which is another natural border. You can check out a map online at Virginiatrace.com - look for the map link.
As everyone else has said, there are advantages and disadvantages to every village location - there really is no BAD location, although everyone thinks theirs is the best. Of course, mine really is
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