We took that route several times and it is OK. However, there are some lights and traffic in the Gainesville area that can slow you down a little. Someone here recommended staying on 301 until just above Ocala (I can't remember the actual highway number) and then cut over to catch 75. This is nice since most of the 301 part is divided highway and the cutoff to get to 75 is very short (a mile or 2) and it avoids the bad part of 301 - the part from Ocala and south.
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