Enterprise in Lake Sumter Landing will do one way rentals between The Villages and the airport. But it might be almost as cheap to just rent a car in Orlando for the 6 or 7 days (with Enterprise or someone else) because they charge you extra for a one way rental than if you are returning the car to the same rental location. The nice thing about Enterprise is that they will pick you up at your house and bring you to Lake Sumter Landing.
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