I agree with the above. Most of those online programs simply empty trash, delete temp files and browser history. I would be leery of anything online that was really going to alter registry settings or other settings.
CCleaner is a really good program. Besides cleaning out trash, it also has the ability to modify your start-up to eliminate unnecessary programs from running in the background. I find this alone often improves performance, especially start-up speed. And, it's free!
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