We have traveled with our 2 cats and dog in our rv all across the country. We kept them in a cage with water and food and would stop every 2 hours and let them out for a potty break and a walk. Never had any problems. The cats would sleep most of the time and our dog would look out the window. All was well. I will say in preparation for travel we would take the cats out for a few short trips so they would get accustomed to the cage and motion of the truck.
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