Try I-77
We have been driving back and forth from Columbus to TV for 5 years now. Much prefer going Rt. 33 to Ravenswood, WV where we get on I-77 thru Charlotte to to I-26 to I-95. This avoids Cincinnati AND Atlanta. We've done it both ways and hands down like the I-77 way, no really big cities to get thru, except for Columbus (we live in the north end) and Charlotte - and the traffic in these doesn't compare to Cincinnati (crossing the river on I-75) and Atlanta (can be a nightmare at any time). Stop in Nelsonville, OH for an Egg McMuffin and a restroom break.
Charlotte, NC is about halfway, total drive about 15 hours, without a lot of stopping. We used to do it in one day when we were working, to save a vacation day. Our best time ever was 14.5 hours. At Jacksonville, you have a choice of I-10 to 301 or go further south on I-95 and thru the Ocala National Forest (nicer drive, but not at the end of a 15 hour trip if you do it in one day - more route changes to look for, but no bad speed trips as on 301 either).
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