What do you want to be close to (or far away from)? How important is it to be close to one of the squares (or not), grocery stores, restaurants, a rec center, and so on.
If you're buying a resale home, we based part of our decision on the age of the house we wanted to have. That alone will point you to certain areas. Also with resales: Do you want natural gas service or not? Some will have it, some won't.
Bill