My husband and I traveled several times from PA to New Orleans (1250 miles) with a Great Pyrenees !130 lbs) 2 borzoi (Russian Wolfhounds) and greyhounds in the back of a Saturn Wagon. The only antsy one was me. We got out for the dogs to stretch their legs frequently and to potty and once, in Mississippi I think, when we piled out of the car someone asked us if we were on tv. It can be done and we did just fine. I took my dogs for short drives to get them used to the car and then off we went.
I am sure you can find someone to rent to you here in TV. I have a home I rent and if it were not rented already I would rent to you. You can at least try. There are many hotels that take dogs.
DogFriendly.comŽ - Pet Travel Guides and City Guides for Dog/Pet Owners this website will tell you dog friendly places to stop, hotels/motels and dog parks near where you will be staying. We always plan our travels around what works for our dogs. Check out the website and see if you can make it work. I think if you are going to be gone a while you will have more peace of mind knwing your dogs are with you, at least I would.