When I came from St. Louis, I put Beta (the then cat) in a small cage - not a carrier - that we'd gotten years before when his sister had to be confined while recuperating from leg surgery. The cage fit between the front seats of my mini-van, so he was close to me, and I could reach in to settle his nerves.
After the first tense 100 miles or so, he settled down, only becoming distressed when some big 18-wheeler roared past us.
Stayed only one night on the road, and Beta was comfortable, so long as I was there, too.
Once here, he explored thoroughly the first couple of nights, I suppose wondering where in h*** all his furniture was. When it came, he seemed pleased to have familiar stuff around.
And, it didn't take more than a couple of days for him to decide that the lanai was COOL!
I agree with redwitch - don't even think about flying!
SWR