Regular pain medications, even opioid-like ones, do not work for fibromyalgia. Low dose amitriptyline works but is only available by prescription. Amitriptyline is an anti-depressant, but it's mechanism of action to mitigate the pain of fibromyalgia is not known--in other words, it's not affecting mood in the case of fibromyalgia because you're not necessarily depressed, it's working on the brain's pain centers, but no one yet knows how. Amitriptyline has an unfortunate side effect of weight gain, but that's less of a problem at low dose. The similar drug nortriptyline has slightly less potential for weight gain and probably would also be affective, but I don't recall ever prescribing nortriptyline for fibromyalgia, only amitriptyline.
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