We have switched to Sentinel for heartworm, tick and flea prevention. We used to use Interceptor, but was discontinued. Seems Sentinel is their replacement. We did try Trifexis for almost a year. We had issues with our dog (20 lbs), every few months, throwing it up within a few hours. Also, he was uncomfortable for the day he took it. He is doing better on the Sentinel. We also had issues with Advantix II. Our dog would try to bite at the application site for days. It appeared to be too strong or caustic for him. We now have switched back to Frontline for the ticks. He has long hair and we do not want a tick collar on him. Both products that we use have flea protection. We use them 2 weeks apart.
They are all poison, but the alternative of possible disease is worse- in my opinion.
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