We just drove home
yesterday from Key West. It took just under 8 hours (maybe 7:45?), from Mallory Square to Mallory Square

.
We used the Florida Turnpike and saw no traffic. We left Key West around 8:15 AM. I averaged about 5-7 MPH over the posted limit on the Turnpike (and I was not the fastest by any means).
It took longer than I thought from Key West to the Turnpike on Route 1, but it is a very pretty drive.
My expertise ends there. It was our first visit and we were only there two days. As Arnold would say "I will be back....". We stayed at the Pier House in what is called a Lanai Room.
This is the view from our second story room. I only had a phone to take pictures with, but you get the jist. Through the trees you can almost make out the pool area.
The Pier House is right on the water. If you have more money than me, this picture is from a deck right under some rooms. I suspect they are the dock side suites? How about this view as you read the paper on your balcony?