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My son is a MD and PHD and teaching professor at the University of Pennsylvania and has reviewed this article. Weight loss or gain is 99.9 percent dependent on caloric intake and caloric burn. There are some thyroid issues and a few rare diseases that represent the other one tenth of one percent. All this study proves is that a very specific genes processes fat differently and has nothing to due with weight gain or loss. There was no double blind study done to show any substantial direct correlation that obese people burn fat differently. The study is intended to make dietitians aware of this but has no real ah ha validity. If you want to loss weight eat less or burn more calories with exercise.