The most likely thing is a fire ant, but that is a large blister. Perhaps your histamine reaction was over the top? If it were me, I'd put the benadryl-type antihistamine cream on it, and an anti-itch cream.
I am not a medical professional, but I've been in Florida a long time.
If the center of the blister becomes necrotic it could be a brown recluse spider bite.
I wait to pop the blister until some of the inflammation subsides.
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