I have had Express Scripts for years since before when they were MEDCO. I live overseas so they must be sent either APO or State Dept. pouch and I really don't have too many problems. If I change addresses (which I do quite often) they like me to call and confirm the change. My doctor now sends the scripts in electronically and I don't have to bother mailing them in myself. Much easier, they always come pretty quickly especially considering they are coming in the pouch. You can also choose auto refill (if refills are authorized) and don't have to worry about reordering.
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