[Bubbalarry]

I found that the best way and quickest was to go by way of I-75 to just south of Gainesville and followed my directions from above. We saved over 30 minutes and avoided most of 301 which is the shortest way in miles but forever by car if you go the full 100 miles to I-10.

Going Rt 42 or anyway towards the coast added many more miles, no matter how the road is it's not direct line of site and takes longer.

When I got back on 301, I only had 35 miles to I-10 and then a very short drive to I-295N.

So in my opinion so far thats the way to go.