On a long-ago 3-day trip with our old Siamese cat Agatha, I gave her a tranq the first day but it knocked her out completely. Next time I gave her half and didn't need any more after that. I put a litter box in the back but she never used it in the car, only at night in the motel. No food in the car. Water in the form of a bowl of ice cubes that melted slowly. No carrier, leash and harness only. Good luck!
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. . .there is nothing better for people than to be happy and to enjoy themselves, and also that everyone should eat and drink, and find enjoyment in all his toil. . .
Ecclesiasites 3:12
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